LT12 has immunoregulating and/or anti-allergic activities. LT12 was capable of stimulating peripheral blood mononuclear cells (PBMCs) isolated from volunteers to secret INF-γ, as demonstrated by ELISA. INF-γ is a cytokine that is critical for innate and adaptive immunity against viral and intracellular bacterial infections. In addition, LT12 was also capable of stimulating PBMCs secretion of other cytokines,

comprising IL-1α, IL-6, IL-10, MCP-2, and TNF-γ. Accordingly, LT12 showed be with immunoregulating and/or anti-allergic activities.

 

LT12 shows tolerance to acid and bile. LT12 is highly resistant to gastric acidity and is able to grow in the presence of bile. It suggested that these abilities correlated to its adhesion capability in gut tract.

 

LT12 has a broadly visible antimicrobial activity. LT12 provides the antagonistic activity against to Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica.

 

LT12 has high antioxidant activity. The antioxidant activities of LT12 were measured by ABST and DPPH free radical scavenging methods. The resulted showed that LT12 has strong antioxidant activity for providing health benefit for host.