•  Scientific literature describes the major role of PAR-2 activation in undesired inflammatoryand itchy skin conditions.

•  High throughput screening of 17000 materials on a PAR-2 expressing HEK cell line andsuccessive evaluation of PAR-2 specificity of primary and secondary screening hits withadvanced screening tools resulted in the identification of SymMollient® WS as an activeingredient with highly specific PAR-2 inhibitory activity.

•  SymMollient® WS was chosen as product development candidate because of its excellentstability and safety records.

•  The soothing efficacy of the PAR-2 inhibitory mode of action of SymMollient® WS wasproven in a clinical study with 20 subjects suffering from itchy scalp.

•  PAR-2 antagonist SymMollient® WS is applicable in a wide range of cosmetic formulationsas skin soothing active ingredient.