Through one of the most innovative bionic technologies: natural deep eutectic solvent (NaDES),we carried out active extraction of FOMES OFFICINALIS (MUSHROOM) to obtain SHINE+ FOMES OFFICINALIS (MUSHROOM) EXTRACT. The active compound co-melt composed of the extract and NaDES can enhance plant activity characteristics and stability. SHINE+ FOMES OFFICINALIS (MUSHROOM) EXTRACT can increase the moisture content of keratin, shrink pores, and reduce inflammatory, adjust the balance of water and oil, and improve acne-prone skin.