Nano-encapsulated HPR is a new type of nano-liposome preparation, which is the first patented product in China. Hydroxy bergenone retinyl ester (HPR), designed with precursor drug technology, can bind directly to cellular retinoic acid receptors (RARs). Nanoencapsulated HPR solves the safety and compliance problems of retinoic acid in skin care products, effectively expands the application field and applicable population of vitamin A active substance, and benefits more consumers.