Through density functional theory, thermodynamic and kinetic theoretical calculations and high-throughput screening technology, Shinesky selects the functional material as precursors and conducts supramolecular modification to form the supramolecular eutectic compounds with significant efficacy and relatively stable structure.Therefore, it can improve the solubility, stability, irritation and efficacy of natural functional raw materials, and we can break the limitation of its application in formulation.Supramolecular chemistry technology has the advantages of strong design and high universality, which can be widely used in the optimization and modification of most natural functional raw materials.