Ligfactor-P is a water soluble pearl polypeptide lyophilized powder. Through the mechanism study, the new whitening raw material can not only inhibit the melanin generation pathway initiated by α-MSH and ET-1, but also actively inhibit the activity of MITF through the epigenetic mechanism by promoting the content of miRNA, thus reducing the ability of melanin synthesis. An SCI study on endothelin antagonism against whitening has been published in Journal of Cosmetic Dermatology. Based on the three key melanin synthesis pathway, signal transmission, the synthesis of melanin and melanin transhipment, Ligfactor-P can be respectively in the field of cuticle, epidermis base layer two, does not affect cell growth, prevent and active black suppression ability, eventually make up the present security, inverse black whitening ingredients.