iLiver™ Longan Shell Extract
Liver injury and fatty liver can lead to chronic hepatitis, brosis even liver cancer. In this study, we found iLiver™ Longan shell extract has
hepatoprotective activity to ght against a liver injury and fatty liver. According to our in vitro study, 4mg/ml iLiver™ Longan shell extract
signicantly reduced lipid droplet formation in HepG2 cell by 40.5%. The mRNA level of hepatic lipogenesis genes including SREBP-1c, SCD-1,
and ACC all declined after the iLiver™ treatment. Pre-treating HepG2 cell with iLiver™ could prevent 90% of hepatocytes from oxidative
damage under hydrogen peroxide condition, indicating that iLiver™ Longan shell has hepatoprotective potential. In addition, our human in
vivo study found that consuming 3g of iLiver™ daily for eight weeks, showed a promising hepatoprotective activity by reducing in serum level
of triglyceride, total cholesterol, LDL, insulin resistance, and internal fat. More importantly, the liver ultrasonography result conrmed that
mild fatty liver‑can be reduced by iLiver™ Longan shell extract consumption.
