Hairdian® AP is a natural plant material developed for hair loss. The bioactive ingredients are extracted from Latycladus orientalis, Zingiber officinale, Trifolium pratense and Artemisia argyi using two innovative techniques named ultrasonic-assisted semi bionic extraction and thermal infiltration integrated extraction. It focuses on the regulation of hair follicle cycle and could effectively reduce hair loss via promoting autophagy of dermal papilla cells (DPCs) and up-regulating the expression of some cell growth factors.