BioOcullar, a 3D corneal model developed by Biocell Biotechnology, is the first reorganized tissue model that can be used for eye irritation test in China, which has been implemented for industrial applications.The in vitro eye irritation detection method based on BioOcullar (3D corneal model),can effectively evaluate eye irritation of chemicals and cosmetic products, and has high detection efficiency. It can be widely used in cosmetics raw material screening, product development etc, and provided scientific basis for consumer safety, effective supervision and other regulatory departments.